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Formulation of Cannabidiol in Colloidal Lipid Carriers
Nadine Monika Francke1, Frederic Schneider2, Knut Baumann2,3
1Institute of Pharmaceutical Technology and Biopharmaceutics, Technische Universität Braunschweig, Mendelssohnstraße 1, 38106 Braunschweig, Germany.
Molecules (Basel, Switzerland)
|April 3, 2021
Summary
This study explored formulating cannabidiol (CBD) in lipid emulsions, achieving high drug loads (>40%) in various oils. CBD incorporation impacts particle size and stability, with phospholipid emulsions showing better resilience.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Drug Delivery Systems
Background:
- Cannabidiol (CBD) is a pharmacologically active compound with poor water solubility, necessitating advanced formulation strategies.
- Colloidal lipid emulsions are a recognized approach for delivering lipophilic drugs like CBD.
- Understanding CBD's behavior within lipid carriers is crucial for developing effective pharmaceutical products.
Purpose of the Study:
- To investigate the processability and loading characteristics of cannabidiol (CBD) in various colloidal lipid carriers.
- To analyze the impact of CBD loading on emulsion properties, including particle size and lipid matrix density.
- To assess the stability of CBD-loaded emulsions under stress conditions and compare different stabilization methods.
Main Methods:
- Preparation and characterization of lipid emulsions with varying lipid matrices (medium chain triglycerides, rapeseed oil, soybean oil, trimyristin).
- Quantification of CBD loading capacity in different lipid matrices and comparison with solid lipid nanoparticle suspensions.
- Analysis of CBD localization within emulsion droplets (lipid core vs. interface).
- Stress testing of emulsions to evaluate CBD-induced destabilization and comparative stability of phospholipid- vs. poloxamer-stabilized systems.
Main Results:
- High CBD drug loads (>40% of lipid content) were achieved in multiple lipid matrices.
- The maximum CBD load was dependent on the specific lipid matrix used.
- CBD loading increased particle size and lipid matrix density; trimyristin emulsions showed superior loading capacity (69%) compared to trimyristin SLNs (30%).
- CBD was found in both the lipid core and at the interface of emulsion droplets.
- CBD destabilized emulsions, with phospholipid-stabilized systems exhibiting greater stability than poloxamer-stabilized ones.
- Pure CBD emulsions were successfully produced due to CBD's significant supercooling tendency, preventing recrystallization down to -60 °C.
Conclusions:
- Colloidal lipid emulsions are highly effective carriers for achieving substantial cannabidiol (CBD) loading.
- CBD's interaction with lipid emulsions influences droplet characteristics and overall formulation stability.
- The supercooling property of CBD enables the creation of unique, stable liquid CBD-dispersed systems.
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