Related Experiment Video

Updated: Nov 10, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

9.1K

Targeting Genome Stability in Melanoma-A New Approach to an Old Field

Marta Osrodek1, Michal Wozniak1

  • 1Department of Molecular Biology of Cancer, Medical University of Lodz, 92-215 Lodz, Poland.

International Journal of Molecular Sciences
|April 3, 2021
PubMed

Insights

Targeting melanoma genome stability enhances treatment efficacy. This approach may improve outcomes for patients with this resistant skin cancer by increasing sensitivity to current therapies.

Area of Science:

  • Oncology
  • Dermatology
  • Cancer Biology

Background:

  • Cutaneous melanoma remains a treatment-resistant malignancy despite advances.
  • Conventional chemotherapy is often ineffective, shifting focus to targeted therapies.
  • Molecularly targeted therapies like RAS/RAF/MEK/ERK (MAPK) pathway inhibitors show limited long-term benefit due to resistance.

Purpose of the Study:

  • To review recent developments in melanoma research.
  • To explore the role of targeting genome stability in melanoma treatment.
  • To assess the potential of enhancing current therapies by manipulating melanoma cell genome stability.

Main Methods:

  • Review of current scientific literature on melanoma treatment resistance.
  • Analysis of the interplay between DNA repair mechanisms and therapeutic response.
  • Evaluation of studies investigating genome instability as a therapeutic target.

Main Results:

  • Melanoma cells utilize DNA repair for survival during drug treatment.
  • Genome instability can enhance the efficacy of MAPK inhibitors and immunotherapy.
  • Targeting genome stability presents a promising strategy to overcome treatment resistance.

Conclusions:

  • Manipulating melanoma genome stability may overcome resistance to targeted therapies and immunotherapy.
  • Enhancing genome instability could be a key strategy to improve durable responses in melanoma patients.
  • Future therapeutic strategies should consider targeting genome stability to maximize treatment efficacy.
Keywords:
DNA damageDNA repairMAPK inhibitorsdrug resistanceimmune checkpoint inhibitorsmelanomatargeted therapy

More Related Videos

A 3D Organotypic Melanoma Spheroid Skin Model08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

16.2K
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.6K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.0K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.8K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.3K
DNA Damage can Stall the Cell Cycle02:37

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
9.7K
DNA Damage Can Stall the Cell Cycle02:37

DNA Damage Can Stall the Cell Cycle

2.8K
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
2.2K