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Intestinal calcium absorption in man during lithium therapy.

B B Kvinesdal1

  • 1Ib Hornum Department of Internal Medicine, Fredericia Hospital, Denmark.

Mineral and Electrolyte Metabolism
|January 1, 1988
PubMed
Summary

Lithium therapy alters intestinal calcium absorption, with most patients showing decreased absorption and reduced urinary calcium excretion. This suggests calcium retention, potentially accumulating intracellularly, without affecting serum calcium levels.

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Area of Science:

  • Biochemistry
  • Nephrology
  • Pharmacology

Background:

  • Lithium is a mood stabilizer used in treating bipolar disorder.
  • Calcium homeostasis is crucial for various physiological processes.
  • The impact of lithium on calcium metabolism requires further elucidation.

Purpose of the Study:

  • To investigate the effect of lithium therapy on intestinal calcium absorption.
  • To assess changes in urinary calcium excretion and serum calcium levels during lithium treatment.

Main Methods:

  • Calcium absorption was measured in 11 patients before and after 4 weeks of lithium therapy.
  • Urinary calcium excretion and serum calcium levels were monitored throughout the study.

Main Results:

  • Intestinal calcium absorption showed variable responses, decreasing in 6 patients and increasing in 5.
  • A significant 55% relative reduction in urinary calcium excretion was observed in all patients.
  • Serum calcium levels remained unchanged during lithium therapy.

Conclusions:

  • Lithium therapy appears to induce calcium retention, likely through intracellular accumulation.
  • The observed changes in calcium metabolism warrant further investigation into lithium's long-term effects.

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