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Alphacalcidol and renal function in normal subjects.

E Tvedegaard¹, S Madsen

¹Medical Department P, Rigshospitalet, Copenhagen, Denmark.

Mineral and Electrolyte Metabolism

|January 1, 1988

Summary

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Treatment with alphacalcidol (1 alpha OHD3) in healthy adults led to a reversible decrease in renal function. This occurred despite no significant changes in serum calcium or phosphate levels.

Area of Science:

Nephrology
Endocrinology
Pharmacology

Background:

Alphacalcidol (1 alpha OHD3) is a vitamin D analog.
Its effects on renal function in healthy individuals require further elucidation.

Purpose of the Study:

To investigate the impact of short-term alphacalcidol administration on renal function in young healthy adults.

Main Methods:

Sixteen healthy adults received 1 microgram of alphacalcidol orally per day for 3 weeks.
Renal function tests, including serum calcium, phosphate, creatinine, inulin clearance, 51Cr-EDTA clearance, and creatinine clearance, were performed pre-treatment, post-treatment, and post-cessation.

Main Results:

No significant changes in serum calcium or phosphate concentrations were observed.

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A significant increase in serum calcium-phosphorus product and urinary calcium excretion was noted.

A small but significant decrease (p < 0.05) in total plasma clearance rate of 51Cr-EDTA and 24-hour endogenous creatinine clearance was observed.

Inulin clearance showed a non-significant decrease of 4% (p = 0.11).

Conclusions:

Short-term administration of alphacalcidol at a modest dose can lead to a reversible decline in renal function in healthy individuals.
The observed renal functional changes occur without significant alterations in serum calcium or phosphate levels.