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Correction: Senguttuvan et al. The Anti-Cancer Role of Pterostilbene in Endometrial Cancer: A Phase II Prospective, Randomized, Window-of-Opportunity Clinical Trial with Megestrol Acetate. <i>Antioxidants</i> 2025, <i>14</i>, 345.

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Pterostilbene in Cancer Therapy.

Elena Obrador1, Rosario Salvador-Palmer1, Ali Jihad-Jebbar1

  • 1Department of Physiology, Faculty of Medicine and Odontology, University of Valencia, 15 Av. Blasco Ibañez, 46010 Valencia, Spain.

Antioxidants (Basel, Switzerland)
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PubMed
Summary
This summary is machine-generated.

Pterostilbene (PT) shows in vivo anticancer activity against melanoma by inhibiting brain hormone production, weakening tumor defenses, and promoting cancer cell death. PT is safe and shows potential as an adjuvant cancer therapy.

Keywords:
cancerheat-shock proteinsoxidative stresspolyphenolspterostilbenestilbenes

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Area of Science:

  • Natural products chemistry
  • Pharmacology
  • Cancer biology

Background:

  • Natural polyphenols have antitumor properties but suffer from poor bioavailability.
  • Pterostilbene (PT), a natural polyphenol, demonstrates in vivo efficacy against melanoma, but not in vitro.

Purpose of the Study:

  • To elucidate the in vivo anticancer mechanism of Pterostilbene (PT) against melanoma.
  • To evaluate the safety and potential of PT as an adjuvant cancer therapy.

Main Methods:

  • Investigated PT's effect on adrenocorticotropic hormone production and Nrf2-dependent antioxidant defenses in mice.
  • Examined PT-induced cancer cell death via lysosomal membrane permeabilization.
  • Assessed PT's safety and toxicity in mice following intravenous administration.

Main Results:

  • PT inhibits melanoma growth in vivo by reducing brain hormone production, thereby weakening tumor antioxidant defenses and sensitizing cancer cells to oxidative stress.
  • PT induces cancer cell death through lysosomal membrane permeabilization, with efficacy varying based on lysosomal heat shock protein 70 content.
  • PT was found to be safe and well-tolerated in mice, even at high intravenous doses.

Conclusions:

  • Pterostilbene (PT) exhibits significant in vivo anticancer activity and is pharmacologically safe.
  • PT's unique mechanism of action and safety profile position it as a promising adjuvant or sensitizing therapy for various oncotherapies.