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Related Concept Videos

Role of Septins01:02

Role of Septins

1.9K
Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
1.9K
Septins01:19

Septins

2.0K
Septins are protein filaments forming the cytoskeleton along with the microtubules, microfilaments, intermediate filaments, and other accessory proteins. In 1971 while studying the cell division cycle in mutant Saccharomyces cerevisiae Harwell et al. first identified the septin-related genes playing a crucial role in yeast cytokinesis. Fluorescence microscopy revealed that these proteins localize at the budding neck as rings. These ring-like proteins were then named Septins by John Pringle, and...
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Intracellular Movement of Viruses and Bacteria01:10

Intracellular Movement of Viruses and Bacteria

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Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
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Viral Structure00:56

Viral Structure

69.6K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
69.6K
SNAREs and Membrane Fusion01:43

SNAREs and Membrane Fusion

11.7K
Once a transport vesicle has recognized its target organelle, the vesicular membrane needs to fuse with the target membrane to unload the cargo. Transmembrane proteins called SNAREs present on organelle membranes and their vesicles, mediate vesicle fusion.
SNAREs exist in pairs that symmetrically interact and catalyze the fusion of the lipid bilayers in vesicle and target organelle. v-SNARE in the vesicle membrane are single polypeptide chains that bind to a complementary t-SNARE, composed of 2...
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siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

17.5K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
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Related Experiment Video

Updated: Nov 10, 2025

Purification and Quality Control of Recombinant Septin Complexes for Cell-Free Reconstitution
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Purification and Quality Control of Recombinant Septin Complexes for Cell-Free Reconstitution

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Septins in Infections: Focus on Viruses.

Thomas Henzi1, Nils Lannes1, Luis Filgueira1

  • 1Anatomy Unit, Department of Oncology, Microbiology and Immunology, Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland.

Pathogens (Basel, Switzerland)
|April 3, 2021
PubMed
Summary
This summary is machine-generated.

Human septins are cytoskeletal proteins involved in various cellular functions and diseases. This review explores their roles in viral infections, highlighting limited knowledge on specific septin functions during virus replication cycles.

Keywords:
cytoskeletonseptinvirus infection

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Bottom-Up In Vitro Methods to Assay the Ultrastructural Organization, Membrane Reshaping, and Curvature Sensitivity Behavior of Septins
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Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions
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Bottom-Up In Vitro Methods to Assay the Ultrastructural Organization, Membrane Reshaping, and Curvature Sensitivity Behavior of Septins
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Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions
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Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions

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Area of Science:

  • Cell Biology
  • Virology
  • Molecular Biology

Background:

  • Septins are a family of 13 conserved GTP-binding proteins in humans.
  • They function as cytoskeletal elements, interacting with actin and microtubules, and binding to membranes.
  • Septins are involved in diverse cellular processes like cytokinesis, motility, and vesicle transport.

Purpose of the Study:

  • To review the known functions of human septins in viral infections.
  • To discuss the implications of septins in the replication cycles of significant public health viruses.
  • To identify knowledge gaps regarding specific septin roles in viral pathogenesis.

Main Methods:

  • Literature review of published data on septins and viral infections.
  • Focus on viruses including vaccinia virus (VACV), hepatitis C virus (HCV), influenza A virus (H1N1, H5N1), human herpesvirus 8 (HHV-8), and Zika virus (ZIKV).

Main Results:

  • Septin dysfunction is linked to human pathologies such as neurodegeneration and tumorigenesis.
  • Septins influence host-microbe interactions, including fungal, bacterial, and viral infections.
  • Limited data exists on the precise function of individual septins in different stages of viral infection and replication.

Conclusions:

  • Septins play a role in host-pathogen interactions, particularly in viral infections.
  • Further research is needed to elucidate the specific functions of septins in viral replication and pathogenesis.
  • Understanding septin involvement could offer new therapeutic strategies against viral diseases.