Related Experiment Video
Updated: Nov 10, 2025

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles
Published on: October 18, 2024
Autophagy and Extracellular Vesicles in Colorectal Cancer: Interactions and Common Actors?
Clément Auger1, Niki Christou1,2, Aude Brunel1
1EA 3842, CAPTuR, GEIST, Faculty of Medicine, University of Limoges, 2 rue du Dr Marcland, 87025 Limoges CEDEX, France.
Abstract:
Autophagy is a homeostatic process involved in the degradation of disabled proteins and organelles using lysosomes. This mechanism requires the recruitment of specialized proteins for vesicle trafficking, that may also be involved in other types of machinery such as the biogenesis and secretion of extracellular vesicles (EVs), and particularly small EVs called exosomes. Among these proteins, Rab-GTPases may operate in both pathways, thus representing an interesting avenue for further study regarding the interaction between autophagy and extracellular vesicle machinery. Both mechanisms are involved in the development of colorectal cancer (CRC), particularly in cancer stem cell (CSC) survival and communication, although they are not specific to CRC or CSCs. This highlights the importance of studying the crosstalk between autophagy and EVs biogenesis and release.
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