Related Experiment Video

Updated: Nov 10, 2025

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method
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Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method

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Apoptosis-Inducing TNF Superfamily Ligands for Cancer Therapy

Olivia A Diaz Arguello1, Hidde J Haisma1

  • 1Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, 9713AV Groningen, The Netherlands.

Cancers
|April 3, 2021
PubMed

Insights

Apoptosis-inducing ligands show promise for cancer treatment by triggering cancer cell death. Researchers are improving these natural compounds to enhance their effectiveness against tumors.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Cancer cells evade apoptosis, a key hallmark of the disease.
  • Tumor necrosis factor (TNF) ligands, including TNF-α, FasL, and TNF-related apoptosis-inducing ligand (TRAIL), possess natural tumoricidal activity.
  • Targeting apoptosis pathways offers a promising strategy for cancer therapy.

Purpose of the Study:

  • To review the potential of apoptosis-inducing ligands as cancer treatments.
  • To summarize strategies for overcoming the limitations of natural TNF ligands.
  • To assess the preclinical and clinical progress of these agents.

Main Methods:

  • Review of preclinical and clinical studies on TNF family-derived ligands and agonists.
  • Analysis of strategies to improve ligand stability, specificity, and half-life.
  • Examination of approaches to enhance therapeutic effectiveness.

Main Results:

  • Recombinant TNF ligands and agonists have been developed with improved properties.
  • Strategies have been identified to overcome limitations like short half-life and off-target binding.
  • Apoptosis-inducing ligands are progressing through various stages of cancer treatment research.

Conclusions:

  • Apoptosis-inducing ligands represent a promising therapeutic avenue for cancer.
  • Enhancements in ligand design are crucial for improving clinical efficacy.
  • Further research and development are needed to fully realize their potential in cancer therapy.
Keywords:
TNF familyapoptosiscancerdeath receptors

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