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Assessment of Multiple Sclerosis Disability Progression Using a Wearable Biosensor: A Pilot Study.

Gianmarco Abbadessa1, Luigi Lavorgna1, Giuseppina Miele1

  • 1Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

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Summary

Smartwatch accelerometers can reliably measure motor disability in people with multiple sclerosis (pwMS). Step data from smartwatches correlate with disability measures and patient-reported outcomes in pwMS.

Keywords:
accelerometerdigital healthdisability assessment

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Area of Science:

  • Neurology
  • Biomedical Engineering
  • Rehabilitation Medicine

Background:

  • Evaluating walking activity in people with multiple sclerosis (pwMS) is crucial for disease management.
  • Smartwatch accelerometers offer a potential method for objective motor function assessment in pwMS.
  • Correlation between smartwatch-derived motor parameters and established MS disability measures needs investigation.

Purpose of the Study:

  • To assess the correlation between motor parameters from a smartwatch accelerometer and multiple sclerosis (MS) disability measures.
  • To evaluate the relationship between smartwatch data and patient-reported outcomes (PROs) in pwMS.

Main Methods:

  • 25 relapsing-remitting MS patients participated, wearing an accelerometer for 30 days.
  • Disability was assessed using the expanded disability status scale, 2-minute walking test (2MWT), and timed 25-foot walk test (T25FWT).
  • Patient-reported outcomes included measures of fatigue, ambulatory ability, depression, quality of life, and bladder/bowel function.

Main Results:

  • A moderate negative correlation was found between patient-determined disease steps (PDDS) and mean daily steps.
  • A strong negative correlation existed between PDDS and maximum daily steps (MNDS).
  • Moderate negative correlations were observed between MNDS and the 2MWT, T25FWT, and fatigue severity scale.

Conclusions:

  • Motor parameters obtained from smartwatch accelerometers show potential as reliable indicators of motor disability in pwMS.
  • Accelerometer-based data may offer a feasible and objective approach to monitoring MS progression and treatment response.