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Updated: Nov 10, 2025

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Oncolytic Adenoviruses for Cancer Therapy

Lorella Tripodi1,2, Maria Vitale2,3, Vincenzo Cerullo3,4

  • 1SEMM European School for Molecular Medicine, 20123 Milano, Italy.

International Journal of Molecular Sciences
|April 3, 2021
PubMed

Insights

Oncolytic adenoviruses (Onc.Ads) offer a promising cancer immunotherapy approach. Their tumor selectivity and ability to elicit strong T-cell responses enhance anti-cancer efficacy, potentially improving current treatments.

Area of Science:

  • Oncology
  • Immunotherapy
  • Virology

Background:

  • Cancer immunotherapy is rapidly evolving, with a need for novel strategies.
  • Oncolytic adenoviruses (Ads) show promise due to tumor selectivity and transgene delivery.
  • Their inherent immunogenicity is a key strength for anti-cancer responses.

Purpose of the Study:

  • To review adenovirus (Ads) and oncolytic adenovirus (Onc.Ads) applications in cancer therapy.
  • To explore strategies for enhancing Onc.Ads anti-tumoral efficacy.
  • To discuss the role of tumor microenvironment modulation in Onc.Ads therapy.

Main Methods:

  • Literature review of adenovirus and oncolytic adenovirus research.
  • Analysis of strategies to improve Onc.Ads efficacy.
  • Examination of tumor microenvironment modulation techniques.

Main Results:

  • Oncolytic adenoviruses (Onc.Ads) demonstrate significant tumor selectivity and immunogenicity.
  • Enhanced immunogenicity promotes a strong T-cell response against tumors.
  • Strategies exist to improve Onc.Ads efficacy, including microenvironment modulation.

Conclusions:

  • Oncolytic adenoviruses (Onc.Ads) represent a valuable tool in cancer immunotherapy.
  • Onc.Ads can potentiate conventional therapies and immune checkpoint inhibitors (ICIs).
  • Further development of Onc.Ads strategies offers a promising future for cancer treatment.
Keywords:
cancerimmunovirotherapyoncolytic adenovirus

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