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Updated: Nov 10, 2025

Confocal Laser Scanning Microscopy of Calcium Dynamics in Acute Mouse Pancreatic Tissue Slices
Published on: April 13, 2021
Mitochondrial Calcium Signaling in Pancreatic β-Cell
Anna Weiser1,2, Jerome N Feige1, Umberto De Marchi1
1Nestlé Research-EPFL Innovation Park, CH-1015 Lausanne, Switzerland.
Abstract:
Accumulation of calcium in energized mitochondria of pancreatic β-cells is emerging as a crucial process for pancreatic β-cell function. β-cell mitochondria sense and shape calcium signals, linking the metabolism of glucose and other secretagogues to the generation of signals that promote insulin secretion during nutrient stimulation. Here, we describe the role of mitochondrial calcium signaling in pancreatic β-cell function. We report the latest pharmacological and genetic findings, including the first mitochondrial calcium-targeted intervention strategies developed to modulate pancreatic β-cell function and their potential relevance in the context of diabetes.
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