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Updated: Nov 10, 2025

Generation of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments
Published on: February 9, 2020
Neuron-Oligodendrocyte Communication in Myelination of Cortical GABAergic Cells
Elisa Mazuir1, Desdemona Fricker2, Nathalie Sol-Foulon1
1Inserm, CNRS, Paris Brain Institute, ICM, Sorbonne University, Pitié-Salpêtrière Hospital, F-75013 Paris, France.
Abstract:
Axonal myelination by oligodendrocytes increases the speed and reliability of action potential propagation, and so plays a pivotal role in cortical information processing. The extent and profile of myelination vary between different cortical layers and groups of neurons. Two subtypes of cortical GABAergic neurons are myelinated: fast-spiking parvalbumin-expressing cells and somatostatin-containing cells. The expression of pre-nodes on the axon of these inhibitory cells before myelination illuminates communication between oligodendrocytes and neurons. We explore the consequences of myelination for action potential propagation, for patterns of neuronal connectivity and for the expression of behavioral plasticity.
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