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Myocardium-Specific Deletion of Rac1 Causes Ventricular Noncompaction and Outflow Tract Defects

Carmen Leung1, Anish Engineer1, Mella Y Kim1

  • 1Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.

Journal of Cardiovascular Development and Disease
|April 3, 2021
PubMed
Summary

Rac1 deficiency in heart cells disrupts cardiomyocyte development, leading to congenital heart defects like ventricular septal defects and impaired heart growth. This implicates Rac1 signaling in proper heart formation.

Keywords:
Rac1cell polaritycompact myocardiumcongenital heart defectsproliferationtrabeculation

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