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Related Experiment Video

Updated: Nov 10, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Psoriasis: Pathogenesis, Comorbidities, and Therapy Updated.

¹Department of Dermatology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Chiba 2701694, Japan.

International Journal of Molecular Sciences

|April 3, 2021

Summary

This summary is machine-generated.

Psoriasis involves immune dysfunction, keratinocyte issues, and comorbidities. New research explores novel therapeutic targets and treatments for this chronic inflammatory skin disease.

Keywords:

UBA domain containing 1 antimicrobial peptide collagen disease fibroblast gut dysbiosis indoleamine 2,3-dioxygenase 2 innate immune cell metabolic disease nutrient oxidative stress pruritus treatment

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Area of Science:

Immunology
Dermatology
Genetics

Background:

Psoriasis is a chronic inflammatory skin disease linked to abnormal immunity, keratinocyte issues, and comorbidities like arthritis.
Pathogenesis involves indoleamine 2,3-dioxygenase 2 dysfunction, UBA domain containing 1 regulation, and oxidative stress in blood cells.

Discussion:

Biomarkers like elafin, clusterin, and selenoprotein P are identified for psoriasis and metabolic diseases.
Proteomic analysis reveals fibroblast dysfunction, altered signaling, and gut microbiome involvement (Staphylococcus aureus, Streptococcus danieliae).
Psoriasis-associated pruritus has complex immune, nervous, and vascular origins.

Key Insights:

Novel therapies include retinoic-acid-receptor-related orphan nuclear receptor γt inhibitors, IL-36 receptor antagonists, and aryl hydrocarbon receptor agonists.
Antimicrobial peptides and innate immune cells represent potential therapeutic targets.
Shared and distinct pathomechanisms exist between psoriasis and collagen diseases.

Outlook:

Nutrient-based interventions may regulate psoriasis progression.
Further research into novel therapeutic targets and approaches is encouraged.