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Related Concept Videos

Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

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The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
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Differential Effects of Antiseptic Mouth Rinses on SARS-CoV-2 Infectivity In Vitro.

Chuan Xu1, Annie Wang1, Eileen R Hoskin2

  • 1Public Health Research Institute, Rutgers, New Jersey Medical School, 225 Warren Street, Newark, NJ 07103, USA.

Pathogens (Basel, Switzerland)
|April 3, 2021
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Summary

Mouth rinses, including povidone-iodine and hydrogen peroxide, can significantly reduce SARS-CoV-2 infectivity. This study evaluated mouth rinse cytotoxicity and antiviral effects, finding certain rinses effective in suppressing the virus without prolonged cell contact.

Keywords:
SARS-CoV-2antisepticsmouth rinses

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Area of Science:

  • Virology
  • Infectious Diseases
  • Oral Health

Background:

  • Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2) is detectable in asymptomatic individuals' saliva.
  • Mouth rinses may suppress SARS-CoV-2 viral load and reduce transmission.
  • Cytotoxicity of antiseptic mouth rinses requires careful evaluation for antiviral efficacy.

Purpose of the Study:

  • To determine the effect of commercially available mouth rinses and povidone-iodine on SARS-CoV-2 infectivity.
  • To assess mouth rinse-associated cytotoxicity.
  • To establish an infectivity assay minimizing cytotoxicity impacts.

Main Methods:

  • Evaluated cytotoxicity of mouth rinses (Colgate Peroxyl, povidone-iodine, chlorhexidine gluconate, Listerine) on cell viability.
  • Determined antiviral activity against replication-competent and pseudotyped SARS-CoV-2.
  • Used centrifugation to remove mouth rinse from viruses before cell infection to minimize cytotoxicity.

Main Results:

  • Colgate Peroxyl (hydrogen peroxide) and povidone-iodine showed potent antiviral activity, partly due to cytotoxicity.
  • 5% dilutions of Colgate Peroxyl or povidone-iodine completely blocked viral infectivity.
  • 50% dilutions of Listerine or chlorhexidine gluconate were required to completely block infectivity, while 5% had moderate effects.

Conclusions:

  • Mouth rinses can significantly reduce SARS-CoV-2 infectivity.
  • Specific mouth rinses, like hydrogen peroxide and povidone-iodine, demonstrate potent virucidal effects.
  • Mouth rinse use may offer a strategy to reduce SARS-CoV-2 spread.