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Precision Treatment in ACS-Role of Assessing Fibrinolysis

Ying X Gue1,2, Young-Hoon Jeong3, Mohamed Farag2

  • 1Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool L14 3PE, UK.

Journal of Clinical Medicine
|April 3, 2021
PubMed

Insights

Patients with acute coronary syndrome (ACS) face ongoing risks from blood clots. Assessing impaired fibrinolysis, the body's clot-dissolving ability, can identify high-risk individuals for personalized treatment.

Area of Science:

  • Cardiology
  • Thrombosis Research
  • Precision Medicine

Background:

  • Acute coronary syndrome (ACS) patients face residual thrombotic risk despite optimal antiplatelet therapy.
  • Impaired endogenous fibrinolysis contributes significantly to this residual risk.
  • Current risk stratification may not fully capture patients prone to recurrent events.

Purpose of the Study:

  • To investigate the role of endogenous fibrinolysis assessment in identifying high-risk ACS patients.
  • To explore the potential for personalized antithrombotic therapy based on fibrinolytic status.
  • To improve long-term cardiovascular outcomes in ACS patients.

Main Methods:

  • Global assessment of endogenous fibrinolysis.
  • Utilizing a point-of-care assay for fibrinolysis evaluation.
  • Stratifying ACS patients based on cardiovascular risk and fibrinolytic capacity.

Main Results:

  • Impaired endogenous fibrinolysis is a key factor in residual thrombotic risk for ACS patients.
  • A point-of-care assay can identify patients at persistent high cardiovascular risk.
  • Fibrinolysis assessment aids in personalizing antithrombotic therapy.

Conclusions:

  • Global assessment of endogenous fibrinolysis is crucial for identifying high-risk ACS patients.
  • Personalized antithrombotic strategies targeting fibrinolytic status can improve outcomes.
  • Precision treatment of ACS can be enhanced by incorporating fibrinolysis evaluation.

Keywords:
acute coronary syndromeendogenous fibrinolysisprecision medicine

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