Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

929
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
929
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

804
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
804

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unveiling dry eye disease prior to cataract surgery: A multicenter clinical study.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
Same author

Identification and management of different types of bacillary layer detachment in eyes with rhegmatogenous retinal detachment.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
Same author

Coordinated hand movement sensation revealed through an implanted magnetic prosthetic kinesthetic interface.

Science advances·2026
Same author

Type I to type II Boston keratoprosthesis exchange: a report of two patients.

BMC ophthalmology·2026
Same author

Recombinant Human Nerve Growth Factor in Pediatric Neuropathic Keratopathy: A Focus on Corneal Opacities, Amblyopia, and Visual Outcomes.

Cornea·2026
Same author

Vitreoretinal Complications in Boston Keratoprosthesis Type I and Type II Implants: Timing of Adverse Events and Long-term Outcomes.

Cornea·2026

Related Experiment Video

Updated: Nov 10, 2025

Author Spotlight: Studying Behavior of Acanthamoeba to Develop Targeted Strategies for Preventing Acanthamoeba Keratitis
07:33

Author Spotlight: Studying Behavior of Acanthamoeba to Develop Targeted Strategies for Preventing Acanthamoeba Keratitis

Published on: September 20, 2024

3.0K

Challenges in Acanthamoeba Keratitis: A Review.

Giuseppe Varacalli1, Antonio Di Zazzo1, Tommaso Mori1

  • 1Ophthalmology Operative Complex Unit, Campus Bio-Medico University Hospital, 00128 Rome, Italy.

Journal of Clinical Medicine
|April 3, 2021
PubMed
Summary

Early diagnosis and treatment of Acanthamoeba keratitis (AK) are crucial for better visual outcomes. Delayed diagnosis and management of this serious eye infection can lead to severe vision loss and reduced quality of life.

Keywords:
Acanthamoeba keratitisin vivo confocal microscopymisdiagnosisprognosistherapy

More Related Videos

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.2K
Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis
09:22

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis

Published on: May 12, 2020

5.8K

Related Experiment Videos

Last Updated: Nov 10, 2025

Author Spotlight: Studying Behavior of Acanthamoeba to Develop Targeted Strategies for Preventing Acanthamoeba Keratitis
07:33

Author Spotlight: Studying Behavior of Acanthamoeba to Develop Targeted Strategies for Preventing Acanthamoeba Keratitis

Published on: September 20, 2024

3.0K
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.2K
Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis
09:22

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis

Published on: May 12, 2020

5.8K

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Acanthamoeba keratitis (AK) is a severe microbial keratitis.
  • Diagnosis and management of AK present significant challenges in clinical practice.
  • Delayed treatment negatively impacts patient prognosis and quality of life.

Purpose of the Study:

  • To review challenges in AK diagnosis and management.
  • To identify prognostic factors for AK.
  • To improve patient outcomes and quality of life by preventing misdiagnosis and protracted treatment.

Main Methods:

  • Systematic review of studies on AK published between January 1998 and December 2019.
  • Inclusion of manuscripts detailing clinical manifestations, diagnosis, treatment, prognosis, and management challenges.
  • Analysis of factors influencing short- and long-term outcomes.

Main Results:

  • Diagnosis of AK is frequently challenging and often delayed.
  • A longer interval from symptom onset to therapy initiation correlates with poorer visual outcomes.
  • Timely, standardized antiamoebic therapy improves visual outcomes, shortens treatment duration, and reduces surgical intervention rates.

Conclusions:

  • Timely diagnosis and initiation of appropriate antiamoebic therapy are critical for favorable outcomes in Acanthamoeba keratitis.
  • Missed or delayed diagnosis significantly worsens visual prognosis and impacts patient morbidity.
  • Addressing diagnostic and management challenges is essential for improving patient quality of life.