Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adaptive treatment assignment methods and clinical trials.

R Simon

    Biometrics
    |December 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Adaptive clinical trial designs use accumulating data to assign optimal treatments. Despite rapid growth in adaptive design research, practical application remains limited due to identified deficiencies in current methods.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Comparative strain typing of Rhizobium leguminosarum bv. viciae natural populations.

    Canadian journal of microbiology·2001
    Same author

    Impact of 2,4-diacetylphloroglucinol-producing biocontrol strain Pseudomonas fluorescens F113 on intraspecific diversity of resident culturable fluorescent pseudomonads associated with the roots of field-grown sugar beet seedlings.

    Applied and environmental microbiology·2001
    Same author

    Distal chromosome 17 gains in neuroblastomas detected by comparative genomic hybridization (CGH) are associated with a poor clinical outcome.

    Medical and pediatric oncology·2001
    Same author

    Control of cell fate in plant meristems.

    Novartis Foundation symposium·2001
    Same author

    A molecular link between stem cell regulation and floral patterning in Arabidopsis.

    Cell·2001
    Same author

    Combinatorial peptide libraries as an alternative approach to the identification of ligands for tumor-reactive cytolytic T lymphocytes.

    Cancer research·2001
    Same journal

    Fast penalized generalized estimating equations for large longitudinal functional datasets.

    Biometrics·2026
    Same journal

    Causally-interpretable random-effects meta-analysis.

    Biometrics·2026
    Same journal

    Statistical inference for mean function of partially observed functional time series.

    Biometrics·2026
    Same journal

    Subgroup identification via Interaction Tree and Mixed Model for Repeated Measures with application to Alzheimer's disease.

    Biometrics·2026
    Same journal

    Finite mixtures of linear quantile regressions with concomitant variables: a solution to endogeneity in longitudinal data modeling.

    Biometrics·2026
    Same journal

    Discussion on "INTACT: a method for integration of longitudinal physical activity data from multiple sources" by Jingru Zhang, Erjia Cui, Hongzhe Li, and Haochang Shou.

    Biometrics·2026
    See all related articles

    Area of Science:

    • Biostatistics
    • Clinical Trial Methodology
    • Medical Research

    Background:

    • Adaptive experimental designs leverage accumulating data to optimize patient-treatment allocation in clinical trials.
    • The statistical literature on adaptive designs has expanded significantly, yet practical implementation is notably scarce.
    • Historical development and current trends in adaptive experimental designs are reviewed.

    Purpose of the Study:

    • To provide a comprehensive review of adaptive experimental designs in clinical trials.
    • To evaluate the reasons behind the limited practical application of adaptive designs.
    • To suggest future research directions for developing more applicable adaptive methods.

    Main Methods:

    • Literature review of adaptive experimental designs.

    Related Experiment Videos

  • Historical analysis of adaptive design methodologies.
  • Critical evaluation of existing adaptive design methods for clinical trial suitability.

    • Main Results:

    • Adaptive designs are largely unused in practice despite extensive research.
    • Most published adaptive design methods possess significant deficiencies hindering their application.
    • The current research trajectory may not align with practical clinical trial needs.

    Conclusions:

    • Significant gaps exist between adaptive design research and clinical trial practice.
    • Reorienting research efforts is crucial for developing practically viable adaptive experimental designs.
    • Addressing methodological deficiencies is key to increasing the adoption of adaptive designs in clinical research.