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PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
Published on: December 27, 2013
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Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin-Vitamin E Complex
Shigesaburo Ogawa1, Mai Shinkawa1, Ryuji Hirase2
1Department of Materials and Life Science, Faculty of Science and Technology, Seikei University, Tokyo 180-8633, Japan.
Antioxidants (Basel, Switzerland)
|April 3, 2021
Summary
A new vitamin E (α-tocopherol) delivery system using gamma-cyclodextrin (γ-CD) shows promise for biological applications. This natural composite offers sustained release and cytoprotective effects, enhancing vitamin E
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Antioxidant Research
Background:
- Developing safe and effective antioxidant delivery vehicles is crucial for biological applications.
- Vitamin E (α-tocopherol; Toc) is a potent antioxidant with limited stability and bioavailability in aqueous environments.
- Cyclodextrins (CDs) are known for their ability to form inclusion complexes with various molecules, potentially improving their properties.
Purpose of the Study:
- To develop a novel, biosafety-exerting antioxidant-delivery vehicle using a natural composite of vitamin E and cyclodextrins.
- To investigate the formation and properties of vitamin E-cyclodextrin aggregates in aqueous media.
- To evaluate the sustained release and cytoprotective effects of the developed vehicle for aqua-related biological applications.
Main Methods:
- Formation of natural composites using vitamin E (α-tocopherol; Toc) and different cyclodextrins (β-CD and γ-CD).
- Characterization of Toc-CD aggregates in aqueous media, focusing on water insolubility and dynamics.
- Assessment of the sustained release properties of the aggregated vehicles.
- Evaluation of the cytoprotective effects of the γ-CD-Toc vehicle against oxidative stress.
Main Results:
- Both β-CD and γ-CD formed water-insoluble aggregates with Toc in aqueous solutions.
- The aggregated vehicle, especially the γ-CD-added system, demonstrated a remarkable sustained release effect due to slow dynamics.
- The γ-CD-Toc vehicle exhibited a prominent cytoprotective effect under oxidative stress conditions.
- The study proposed a novel vitamin E vehicle motif using γ-CD as a stabilizer.
Conclusions:
- A novel, natural antioxidant delivery system based on vitamin E (α-tocopherol) and gamma-cyclodextrin (γ-CD) was successfully developed.
- The γ-CD-Toc composite exhibits sustained release properties and significant cytoprotective effects, making it suitable for biological applications.
- This research expands the potential applications of vitamin E in biological contexts by overcoming its limitations through complexation with γ-CD.
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