Related Experiment Video

Updated: Nov 10, 2025

Generation of Human Chimeric Antigen Receptor Regulatory T Cells
10:29

Generation of Human Chimeric Antigen Receptor Regulatory T Cells

Published on: January 3, 2025

2.0K

Regulatory T Cell-Enhancing Therapies to Treat Atherosclerosis

Hafid Ait-Oufella1,2, Jean-Rémi Lavillegrand1, Alain Tedgui1

  • 1Paris Cardiovascular Research Center-PARCC, Université de Paris, INSERM UMR-S 970, 75012 Paris, France.

Cells
|April 3, 2021
PubMed

Insights

Regulatory T cells (Tregs) protect against atherosclerosis by modulating immune responses. Understanding Tregs offers novel therapeutic strategies for cardiovascular disease.

Area of Science:

  • Immunology
  • Cardiovascular Research
  • Inflammation Biology

Background:

  • Atherosclerosis pathogenesis involves chronic inflammation and immune cell infiltration, particularly monocytes/macrophages.
  • Adaptive immunity, including B and T lymphocytes and dendritic cells, significantly influences disease progression.
  • Effector Th1 cells are proatherogenic, while regulatory T cells (Tregs) demonstrate protective effects in atherosclerosis models.

Purpose of the Study:

  • To review the current understanding of regulatory T cells (Tregs) in atherosclerosis.
  • To explore mechanisms by which Tregs influence the atherosclerotic process.
  • To discuss strategies for enhancing Treg function for novel immunomodulatory therapies.

Main Methods:

  • Review of experimental and clinical studies on immune cells in atherosclerosis.
  • Analysis of murine models to differentiate roles of T cell subpopulations.
  • Synthesis of current knowledge on Treg function and therapeutic potential.

Main Results:

  • Tregs play a crucial protective role against atherosclerosis development and progression.
  • Understanding Treg-mediated immune regulation offers insights into disease mechanisms.
  • Targeting Tregs presents a promising avenue for cardiovascular disease treatment.

Conclusions:

  • Regulatory T cells are key modulators of atherosclerosis, offering protective benefits.
  • Enhancing Treg function represents a novel immunomodulatory therapeutic approach.
  • Further research into Treg biology can lead to effective treatments for cardiovascular disease.

Keywords:
T lymphocytesatherosclerosiscytokinesimmunityregulatory T cells

More Related Videos

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.0K
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

9.0K

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.7K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
818
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
100
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
278