Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multiple Sclerosis l: Introduction

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Differences in standing balance by level of upper extremity motor impairment after stroke.

Topics in stroke rehabilitation·2026

Same author

[Gait Training Using Robotic Devices in Subjects With Stroke: An Overview of Systematic Reviews and Meta-analysis].

Revista de neurologia·2026

Same author

Static and dynamic balance in children and adolescents with autism spectrum disorder compared with typically developing peers: a systematic review and meta-analysis.

European journal of pediatrics·2026

Same author

Relationship between motor skills and receptive language in children with autism spectrum disorder.

Human movement science·2026

Same author

Instrumented Assessment of Gait in Pediatric Cancer Survivors: Identifying Functional Impairments After Oncological Treatment-A Pilot Study.

Children (Basel, Switzerland)·2026

Same author

Acute Effects of a Week of Stochastic-Random Whole-Body Vibration on Manual Ability Performance in Healthy Subjects: A Preliminary Pilot Study.

BioMed research international·2025

Search research articles

Related Experiment Video

Updated: Jul 15, 2026

Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion

Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion

Published on: January 15, 2016

Gait Pattern in People with Multiple Sclerosis: A Systematic Review.

María Coca-Tapia¹, Alicia Cuesta-Gómez², Francisco Molina-Rueda²

¹Masters School, Rey Juan Carlos University, 28933 Madrid, Spain.

Diagnostics (Basel, Switzerland)

|April 3, 2021

Summary

People with multiple sclerosis (MS) exhibit altered gait, including reduced speed and stride length. They also show increased double-stance time and specific joint movement changes during walking.

Keywords:

biomechanics gait multiple sclerosis three-dimensional motion capture systems

More Related Videos

Sagittal Plane Kinematic Gait Analysis in C57BL/6 Mice Subjected to MOG35-55 Induced Experimental Autoimmune Encephalomyelitis

Sagittal Plane Kinematic Gait Analysis in C57BL/6 Mice Subjected to MOG35-55 Induced Experimental Autoimmune Encephalomyelitis

Published on: November 4, 2017

Clinical-oriented Three-dimensional Gait Analysis Method for Evaluating Gait Disorder

Clinical-oriented Three-dimensional Gait Analysis Method for Evaluating Gait Disorder

Published on: March 4, 2018

Related Experiment Videos

Last Updated: Jul 15, 2026

Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion

Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion

Published on: January 15, 2016

Sagittal Plane Kinematic Gait Analysis in C57BL/6 Mice Subjected to MOG35-55 Induced Experimental Autoimmune Encephalomyelitis

Sagittal Plane Kinematic Gait Analysis in C57BL/6 Mice Subjected to MOG35-55 Induced Experimental Autoimmune Encephalomyelitis

Published on: November 4, 2017

Clinical-oriented Three-dimensional Gait Analysis Method for Evaluating Gait Disorder

Clinical-oriented Three-dimensional Gait Analysis Method for Evaluating Gait Disorder

Published on: March 4, 2018

Area of Science:

Neurology
Biomechanics
Rehabilitation Science

Background:

Multiple sclerosis (MS) is a chronic neurological disease affecting gait.
Understanding gait alterations is crucial for managing MS progression and patient mobility.

Purpose of the Study:

To systematically review and synthesize findings on gait patterns in individuals with MS.
To consolidate data from studies utilizing 3D human movement capture systems.

Main Methods:

Systematic literature search across PubMed, Web of Science, PEDro, and CINAHL.
Inclusion of studies employing 3D gait analysis (spatiotemporal, kinematic, kinetic, electromyographic parameters).
Quality assessment using the Critical Review Form-Quantitative Studies scale.

Main Results:

12 articles involving 523 individuals (342 women, 181 men) with MS were analyzed.
Key findings indicate decreased gait speed and stride length.
Increased double-stance duration, reduced hip extension, diminished knee flexion, and altered ankle movements (dorsiflexion and plantar flexion) were observed.

Conclusions:

Individuals with MS demonstrate characteristic gait deviations.
These deviations include reduced propulsive forces (hip extensor moment, ankle power) during walking.
Findings highlight the impact of MS on gait biomechanics and functional mobility.