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Lacticaseibacillus paracasei PS23 Effectively Modulates Gut Microbiota Composition and Improves Gastrointestinal
Li-Han Chen1,2, Ming-Fu Wang3, Chun-Chao Chang4,5
1Institute of Fisheries Science, National Taiwan University, Taipei 10617, Taiwan.
Nutrients
|April 3, 2021
Summary
The probiotic Lacticaseibacillus paracasei PS23 (LPPS23) improved gut microbiota and gastrointestinal function in aged mice. LPPS23 enhanced beneficial bacteria, reduced harmful bacteria, and improved gut health markers in aging mice.
Area of Science:
- Microbiology
- Gastroenterology
- Gerontology
Background:
- Probiotics modulate gut microbiota (GM) to improve gastrointestinal (GI) function.
- The specific effects of probiotics on GM and GI function in elderly populations remain unclear.
Purpose of the Study:
- To investigate the impact of Lacticaseibacillus paracasei PS23 (LPPS23) on the gut microbiota and GI function in aged mice.
Main Methods:
- Senescence-accelerated mouse prone-8 (SAMP8) mice were administered low or high doses of LPPS23.
- Gut microbiota composition was analyzed using next-generation sequencing.
- GI function was assessed by measuring intestine length, intestinal permeability, and phagocytosis.
- Pro-inflammatory factors and immunoglobulins were quantified using ELISA.
Main Results:
- LPPS23 administration altered gut microbiota composition, increasing Lactobacillus and Candidatus_Saccharimonas while decreasing Lachnospiraceae_UCG_001.
- LPPS23 treatment improved GI function, evidenced by longer intestine length, reduced intestinal permeability, and enhanced phagocytosis.
- LPPS23 modulated pro-inflammatory factors and immunoglobulins.
- Lactobacillus abundance positively correlated with healthy GI function, while Lachnospiraceae_UCG_001 abundance showed a negative correlation.
Conclusions:
- Lacticaseibacillus paracasei PS23 effectively modulates gut microbiota composition in aged mice.
- LPPS23 demonstrates potential in improving gastrointestinal function and health in aging populations.
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