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Developmental and Neurotoxicity of Acrylamide to Zebrafish
Jong-Su Park1, Palas Samanta1,2, Sangwoo Lee1
1Biosystem Research Group, Korea Institute of Toxicology, Daejeon 34111, Korea.
International Journal of Molecular Sciences
|April 3, 2021
Summary
Acrylamide exposure causes developmental and neurotoxic effects in zebrafish, including physical deformities and impaired movement. This study demonstrates zebrafish as a cost-effective model for assessing acrylamide
Area of Science:
- Toxicology
- Developmental Biology
- Neuroscience
Background:
- Acrylamide is a neurotoxic industrial chemical.
- Assessing its developmental toxicity in mammals is challenging due to cost and complexity.
Purpose of the Study:
- To evaluate the developmental and neurotoxicity of acrylamide using zebrafish.
- To establish zebrafish as a rapid, cost-efficient model for acrylamide toxicity studies.
Main Methods:
- Zebrafish embryos were exposed to acrylamide (10–300 mg/L) for 114 hours.
- Developmental endpoints included physical malformations and swim bladder function.
- Neurotoxicity was assessed via locomotor activity and brain/spinal cord morphology.
Main Results:
- Acrylamide induced developmental toxicity: yolk retention, scoliosis, and body curvature.
- Locomotor activity (swimming speed, distance) was significantly impaired.
- Brain and spinal cord width decreased at 100 mg/L acrylamide, indicating neurotoxicity.
Conclusions:
- Acrylamide exhibits significant developmental and neurotoxic effects in zebrafish.
- Zebrafish serve as a viable model for rapid and cost-effective acrylamide toxicity assessment.
- Findings highlight the need for further investigation into acrylamide's impact on development and the nervous system.
