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Regulation of Long Non-Coding RNAs by Plant Secondary Metabolites: A Novel Anticancer Therapeutic Approach

Mohammad Reza Kalhori1, Hamid Khodayari2,3, Saeed Khodayari2,3

  • 1Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah 6714415185, Iran.

Cancers
|April 3, 2021
PubMed

Insights

Phytochemicals, natural plant compounds, can fight cancer by regulating long non-coding RNAs (lncRNAs). These compounds offer a novel strategy for cancer treatment and prevention.

Area of Science:

  • Molecular Biology
  • Genetics
  • Pharmacology

Background:

  • Long non-coding RNAs (lncRNAs) are crucial regulators of cellular processes like differentiation and apoptosis.
  • Aberrant lncRNA expression is implicated in cancer initiation and progression.
  • Precision medicine tailors cancer treatment to individual genetic profiles.

Purpose of the Study:

  • To review the anticancer effects of phytochemicals through modulation of lncRNA expression.
  • To explore the potential of phytochemicals as alternative cancer therapies.

Main Methods:

  • Literature review of studies investigating phytochemicals and lncRNAs in cancer.
  • Analysis of mechanisms by which phytochemicals regulate oncogenic and tumor suppressor lncRNAs.

Main Results:

  • Phytochemicals can inhibit cancer cell metastasis, proliferation, invasion, and migration by downregulating oncogenic lncRNAs or upregulating tumor suppressor lncRNAs.
  • These natural compounds show potential in enhancing sensitivity to conventional cancer therapies.

Conclusions:

  • Phytochemicals exhibit significant antineoplastic effects via lncRNA regulation.
  • Bioactive plant compounds represent a promising avenue for novel cancer treatment and prevention strategies.
Keywords:
cancer treatmentlncRNAsnatural productsphytochemicalsprecision medicinetargeted therapy

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