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Updated: Nov 10, 2025

Phospho Flow Cytometry with Fluorescent Cell Barcoding for Single Cell Signaling Analysis and Biomarker Discovery
Published on: October 4, 2018
Lessons, Challenges and Future Therapeutic Opportunities for PI3K Inhibition in CLL
Valerio Guarente1, Paolo Sportoletti1
1Department of Medicine and Surgery, Institute of Hematology-Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, 06129 Perugia, Italy.
Abstract:
Chronic lymphocytic leukemia (CLL) shows constitutive phosphatidylinositol 3-kinase (PI3K) activation resulting from aberrant regulation of the B-cell receptor (BCR) signaling. PI3K inhibitors have been evaluated in CLL therapy, bringing a new treatment opportunity for patients with this disease. Despite the proven therapeutic efficacy, the use of approved PI3K inhibitors is limited by severe immune-mediated toxicities and given the availability of other more tolerable agents. This article reviews the relevance of PI3K signaling and pharmacologic inhibition in CLL. Data on efficacy and toxicity of PI3K inhibitors are also presented, as well as strategies for overcoming barriers for their clinical use in CLL treatment.
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