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Anodic Stripping Voltammetry (ASV), Cathodic Stripping Voltammetry (CSV), and Adsorptive Stripping Voltammetry (AdSV) are electrochemical techniques used to determine trace amounts of analytes in solution. These methods involve applying a potential to an electrode and measuring the resulting current.
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Disposable Pencil Graphite Electrode for Diosmin Voltammetric Analysis.

Iulia Gabriela David1, Alexandra-Gabriela Oancea1, Mihaela Buleandră1

  • 1Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Av. 90-92, District 5, 050663 Bucharest, Romania.

Micromachines
|April 3, 2021
PubMed
Summary

This study introduces a new electrochemical method for quantifying diosmin (DIO) using a disposable pencil graphite electrode. The developed voltammetric techniques offer sensitive and reliable detection of diosmin in supplements.

Keywords:
adsorptive stripping voltammetrycyclic voltammetrydietary supplementsdifferential pulse voltammetrydiosmindisposable working electrodepencil graphite electrode

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Area of Science:

  • Electrochemistry
  • Analytical Chemistry
  • Materials Science

Background:

  • Diosmin (DIO) is a naturally occurring flavonoid with significant health benefits.
  • Its chemical structure, featuring hydroxyl groups, allows for electrochemical analysis.
  • Developing cost-effective and accessible quantification methods is crucial.

Purpose of the Study:

  • To investigate the voltammetric behavior of diosmin (DIO) on a pencil graphite electrode (PGE).
  • To develop and optimize electrochemical methods for sensitive diosmin quantification.
  • To validate the method by analyzing diosmin in dietary supplement tablets.

Main Methods:

  • Electrochemical investigation of diosmin oxidation on a disposable pencil graphite electrode (PGE).
  • Optimization of differential pulse voltammetry (DPV) and adsorptive stripping differential pulse voltammetry (AdSDPV).
  • Quantification in 0.100 mol/L H2SO4, assessing pH-dependence and adsorption control.

Main Results:

  • Diosmin oxidation on PGE occurs in two irreversible, pH-dependent steps, controlled by adsorption.
  • Optimized DPV and AdSDPV methods achieved low limits of detection for diosmin.
  • DPV method demonstrated high accuracy (99.87 ± 4.88% recovery) in quantifying diosmin in dietary supplements.

Conclusions:

  • The disposable pencil graphite electrode (PGE) provides a cost-effective platform for diosmin electrochemical analysis.
  • Optimized DPV and AdSDPV methods offer sensitive and reliable quantification of diosmin.
  • The developed electrochemical method is suitable for the practical analysis of diosmin in pharmaceutical formulations.