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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
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Hyperventilation refers to a higher-than-normal rate and depth of breathing, often associated with anxiety attacks. This excessive breathing surpasses the body's need to expel CO2, leading to a condition known as hypocapnia - an unusually low level of carbon dioxide in the blood. Hypocapnia can constrict cerebral blood vessels, reducing blood flow to the brain, which may result in dizziness or fainting. Early signs include tingling and muscle spasms in the hands and face, caused by falling...
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Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
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Related Experiment Video

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Resting Energy Expenditure Is Elevated in Asthma.

Jacob T Mey1,2, Brittany Matuska2, Laura Peterson2

  • 1Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.

Nutrients
|April 3, 2021
PubMed
Summary

Adults with mild asthma exhibit elevated resting energy expenditure (REE) compared to healthy individuals, even with similar body composition. This suggests a link between asthma

Keywords:
airway inflammationbody compositionnutritionrespiratory functionresting energy expenditure

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Area of Science:

  • Physiology
  • Respiratory Medicine
  • Metabolism

Background:

  • Asthma impacts respiratory function and inflammation.
  • These factors may influence resting energy expenditure (REE) and body composition.

Purpose of the Study:

  • To test the hypothesis that asthma is associated with elevated REE compared to weight-matched healthy controls.
  • Investigate the relationship between asthma, REE, and body composition.

Main Methods:

  • Indirect calorimetry to measure REE.
  • Dual-energy X-ray absorptiometry (DEXA) for body composition analysis.
  • Spirometry, fractional exhaled nitric oxide (FENO), and blood counts were assessed.

Main Results:

  • Asthmatics showed approximately 100 kcal/day higher REE than controls, with similar BMI and body composition.
  • Asthma status and FENO improved REE prediction equations.
  • Elevated white blood cell and neutrophil counts in asthmatics correlated with higher REE.

Conclusions:

  • Resting energy expenditure is elevated in adults with mild asthma.
  • Findings suggest an association between REE and asthma pathophysiology.