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Factors Influencing Heart Rate01:30

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The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
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Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
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Tachycardia is a condition marked by an abnormally fast or irregular heart rate, surpassing the typical resting rate. In adults, tachycardia is characterized by a pulse rate ranging from 100 to 180 beats per minute. The increased heart rate can result in inadequate blood flow to various body parts, ultimately diminishing the oxygen supply to organs and tissues.
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Resting Heart Rate as a Predictor of Cancer Mortality: A Systematic Review and Meta-Analysis.

Diana P Pozuelo-Carrascosa1,2, Iván Cavero-Redondo1,3, I M Lee4,5

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A higher resting heart rate (RHR) is linked to an increased risk of cancer mortality. Conversely, a lower RHR may indicate a reduced risk of cancer death.

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Area of Science:

  • Cardiology
  • Oncology
  • Epidemiology

Background:

  • Resting heart rate (RHR) is a physiological indicator influenced by various factors.
  • Previous research suggests potential links between RHR and cardiovascular health.
  • The association between RHR and cancer mortality requires further synthesis of available evidence.

Purpose of the Study:

  • To synthesize existing evidence on the relationship between resting heart rate (RHR) and cancer mortality risk.
  • To conduct meta-analyses to quantify the association between different RHR levels and cancer mortality.
  • To investigate the dose-response relationship between RHR and cancer mortality.

Main Methods:

  • A comprehensive computerized literature search was conducted across major databases (Medline, EMBASE, Web of Science, Cochrane Library) up to September 24, 2020.
  • Three meta-analyses were performed: comparing RHR categories (<60 bpm vs. >60 bpm; <60 bpm, 60-80 bpm, >80 bpm), and dose-response analyses for RHR increases.
  • Twenty-two studies were included in the qualitative review, with twelve meeting criteria for meta-analysis.

Main Results:

  • A positive association was observed between higher resting heart rate (RHR) and an increased risk of cancer mortality.
  • This association was consistent across meta-analyses comparing different RHR categories and in dose-response analyses.
  • An increase of 10-12 bpm in RHR was associated with a higher risk of cancer mortality in both men and women.

Conclusions:

  • Elevated resting heart rate (RHR) is associated with an increased risk of cancer mortality.
  • A lower RHR may serve as a potential biomarker for a reduced risk of cancer mortality.
  • Further research may explore the underlying mechanisms connecting RHR and cancer risk.