Related Experiment Video
Updated: Nov 10, 2025

Establishment of an Extracellular Acidic pH Culture System
Published on: November 19, 2017
Targeting the Hypoxic and Acidic Tumor Microenvironment with pH-Sensitive Peptides
Nayanthara U Dharmaratne1, Alanna R Kaplan1, Peter M Glazer1,2
1Department of Therapeutic Radiology, Yale University, New Haven, CT 06520, USA.
Abstract:
The delivery of cancer therapeutics can be limited by pharmacological issues such as poor bioavailability and high toxicity to healthy tissue. pH-low insertion peptides (pHLIPs) represent a promising tool to overcome these limitations. pHLIPs allow for the selective delivery of agents to tumors on the basis of pH, taking advantage of the acidity of the hypoxic tumor microenvironment. This review article highlights the various applications in which pHLIPs have been utilized for targeting and treating diseases in hypoxic environments, including delivery of small molecule inhibitors, toxins, nucleic acid analogs, fluorescent dyes, and nanoparticles.
More Related Videos
07:32Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
Published on: September 30, 2019
08:26MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression
Published on: February 17, 2012
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against...
The Tumor Microenvironment
Tumor Immunotherapy
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...