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A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
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Harnessing the Benefits of Endogenous Hydrogen Sulfide to Reduce Cardiovascular Disease

Kevin M Casin1, John W Calvert1

  • 1Carlyle Fraser Heart Center, Division of Cardiothoracic Surgery, Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA.

Antioxidants (Basel, Switzerland)
|April 3, 2021
PubMed

Insights

This review explores how the body

Area of Science:

  • Biochemistry
  • Cardiology
  • Metabolic Disorders

Background:

  • Cardiovascular disease is a leading cause of death.
  • Exogenous hydrogen sulfide (H2S) shows therapeutic benefits.
  • The role of endogenous H2S in cardiovascular health is less understood.

Purpose of the Study:

  • To review the role of endogenous H2S in diabetic cardiomyopathy and heart failure.
  • To discuss therapeutic strategies targeting endogenous H2S production.
  • To highlight H2S-modulating enzymes as a promising research area.

Main Methods:

  • Literature review of studies on endogenous H2S.
  • Focus on diabetic cardiomyopathy and heart failure models.
  • Examination of interventions like intermittent fasting and exercise.

Main Results:

  • Endogenous H2S production is a key factor in cardiovascular health.
  • Diabetic cardiomyopathy is influenced by endogenous H2S levels.
  • Intermittent fasting and exercise can stimulate H2S production.

Conclusions:

  • Modulating endogenous H2S offers a novel therapeutic approach for heart failure.
  • Targeting H2S-producing enzymes (CBS, CGL, MPST) is a promising strategy.
  • Lifestyle interventions like fasting and exercise may enhance cardiovascular protection via H2S.

Keywords:
cardiovascular diseasediabetic cardiomyopathyexercisefastingheartheart failurehydrogen sulfidemetabolism

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