CircRNA-Protein Interactions in Muscle Development and Diseases

Area of Science:

• Molecular Biology
• Genetics
• Biochemistry

Background:

• Circular RNAs (circRNAs) are novel endogenous noncoding RNAs formed via mRNA precursor back-splicing.
• RNA-binding proteins (RBPs) regulate circRNA biogenesis, degradation, transport, localization, and translation.
• circRNAs and associated RBPs are vital for biological functions, impacting animal development and disease.

Purpose of the Study:

• To systematically characterize the molecular mechanisms of circRNA-protein interactions.
• To summarize current research on circRNA-RBP interactions in muscle development and myocardial disease.
• To discuss the future therapeutic applications of circRNAs in muscle diseases.

Main Methods:

• Systematic review of literature on circRNA-protein interactions.
• Characterization of molecular mechanisms governing these interactions.
• Summary of experimental and prediction methods for studying circRNA-RBP interactions.

Main Results:

• circRNA-RBP interactions are critical regulators of gene expression and cellular processes.
• These interactions play significant roles in muscle development and the pathogenesis of myocardial diseases.
• Various prediction and experimental methods are available for studying circRNA-RBP interactions.

Conclusions:

• circRNAs and their protein chaperones are significant players in biological functions and disease.
• Understanding circRNA-RBP interactions offers potential therapeutic strategies for muscle-related disorders.
• This review serves as a valuable reference for future research in the field of circRNAs and RBPs.