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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Merkel Cell Carcinoma: New Trends.

Ellen M Zwijnenburg1, Satish F K Lubeek2, Johanna E M Werner3

  • 1Department of Radiation Oncology, Radboudumc, 6525GA Nijmegen, The Netherlands.

Cancers
|April 3, 2021
PubMed
Summary

Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer. This review covers MCC tumor biology, diagnosis, and treatments, highlighting immunotherapy potential and the need for multidisciplinary care.

Keywords:
Merkel cell carcinomabiomarkersimmunotherapyradiotherapysurgery

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Area of Science:

  • Oncology
  • Dermatology
  • Immunology

Background:

  • Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer primarily affecting the elderly.
  • MCC incidence is increasing due to population aging, increased sun exposure, and immunosuppression.
  • Early detection and prompt treatment are crucial due to the tumor's rapid progression.

Purpose of the Study:

  • To review the tumor biology and immunology of Merkel cell carcinoma.
  • To discuss current and emerging diagnostic and treatment strategies for MCC.
  • To emphasize the potential of immunotherapy for this immunogenic tumor.

Main Methods:

  • Literature review of MCC tumor biology, immunology, diagnosis, and treatment.
  • Analysis of current therapeutic modalities and novel combined therapies.
  • Discussion of the role of multidisciplinary team management.

Main Results:

  • MCC is a highly immunogenic tumor with significant potential for immunotherapy.
  • Advances in immunohistochemistry have improved MCC recognition.
  • Aggressive tumor behavior necessitates timely intervention.

Conclusions:

  • Merkel cell carcinoma management requires a collaborative, multidisciplinary approach.
  • Immunotherapy offers promising prospects for treating MCC.
  • Further research into novel and combined therapies is warranted.