Related Experiment Video

Updated: Nov 10, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

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MicroRNAs Regulating Hippo-YAP Signaling in Liver Cancer

Na-Hyun Lee1,2, So Jung Kim1,2, Jeongeun Hyun1,2,3

  • 1Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Korea.

Biomedicines
|April 3, 2021
PubMed

Insights

MicroRNAs (miRNAs) interact with the Hippo-YAP/TAZ pathway to drive liver cancer. Understanding these interactions offers new biomarkers and treatments for liver cancer patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Liver cancer is a global health concern with rising mortality due to limited biomarkers and treatments.
  • The Hippo signaling pathway regulates liver size; its disruption activates YAP/TAZ, leading to liver cancer in mice.
  • YAP/TAZ signaling reprogram tumor cells and modify the tumor microenvironment, contributing to liver tumorigenesis.

Purpose of the Study:

  • To review the role of microRNAs (miRNAs) in liver tumorigenesis.
  • To explore the interactions between miRNAs and the Hippo-YAP/TAZ signaling pathway in liver cancer.
  • To identify potential miRNA biomarkers and therapeutic targets for liver cancer.

Main Methods:

  • Literature review of studies on miRNAs, Hippo-YAP/TAZ signaling, and liver cancer.
  • Analysis of how miRNAs modulate Hippo-YAP/TAZ signaling in hepatic tumorigenesis.
  • Synthesis of findings on miRNA involvement in tumor cell proliferation, migration, and apoptosis.

Main Results:

  • miRNAs play critical roles in liver cancer pathogenesis.
  • Specific miRNAs influence tumor cell behavior by modulating Hippo-YAP/TAZ signaling.
  • These miRNAs are implicated in hepatic tumorigenesis.

Conclusions:

  • miRNAs are key regulators in the Hippo-YAP/TAZ pathway during liver cancer development.
  • miRNAs hold promise as diagnostic and prognostic biomarkers for liver cancer.
  • Targeting these miRNAs could offer novel therapeutic strategies for liver cancer.
Keywords:
Hippo kinaseYes-associated proteincancer therapydiagnosishepatocellular carcinomaliver diseasemicroRNAsprognosis

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