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Nectin Cell Adhesion Molecule 4 (NECTIN4) Expression in Cutaneous Squamous Cell Carcinoma: A New Therapeutic Target?

Yuka Tanaka1, Maho Murata1, Yoshinao Oda2

  • 1Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

Biomedicines
|April 3, 2021
PubMed

Insights

Nectin cell adhesion molecule 4 (NECTIN4) is expressed in cutaneous squamous cell carcinoma (cSCC) and regulates cell attachment, migration, and proliferation. Targeting NECTIN4 may offer a new therapeutic strategy for this common skin cancer.

Area of Science:

  • Oncology
  • Dermatology
  • Cell Biology

Background:

  • Cutaneous squamous cell carcinoma (cSCC) is a prevalent skin cancer with increasing incidence.
  • Nectin cell adhesion molecule 4 (NECTIN4) is implicated in tumor progression, but its role in cSCC is largely unknown.

Purpose of the Study:

  • To investigate the expression and functional significance of NECTIN4 in cSCC.
  • To evaluate NECTIN4 as a potential therapeutic target for cSCC.

Main Methods:

  • Immunohistochemical analysis of NECTIN4 expression in 34 cSCC patient tissues.
  • In vitro studies using an A431 human SCC cell line to assess NECTIN4's role in cell-cell attachment, migration, and proliferation.

Main Results:

  • NECTIN4 is expressed in the majority of cSCC tissues and on the plasma membrane of SCC cells.
  • NECTIN4 silencing disrupted cell-cell attachment, increased migration, downregulated ERK signaling, reduced cyclin D1, and inhibited proliferation.

Conclusions:

  • NECTIN4 plays a crucial role in regulating cell-cell interactions, migration, and proliferation in cSCC.
  • Targeting NECTIN4 presents a promising novel therapeutic approach for cSCC treatment.
Keywords:
NECTIN4antibody-drug conjugatecutaneous squamous cell carcinomatargeted therapy

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