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Hydrotropic solubilization of nifedipine
N K Jain1, V V Patel, L N Taneja
1Pharmacy Department, Faculty of Technology and Engineering, M.S. University of Baroda, India.
Die Pharmazie
|March 1, 1988
Summary
Sodium benzoate and sodium salicylate significantly enhance the solubility of nifedipine, a poorly water-soluble drug. This hydrotropic solubilization is crucial for improving drug delivery and formulation of nifedipine.
Area of Science:
- Pharmaceutical Sciences
- Physical Chemistry
Background:
- Nifedipine is a widely used medication with poor aqueous solubility, limiting its bioavailability.
- Developing effective solubilization methods is critical for pharmaceutical formulations.
Purpose of the Study:
- To investigate the hydrotropic solubilization of nifedipine using sodium benzoate and sodium salicylate.
- To elucidate the mechanism underlying the enhanced solubility of nifedipine.
Main Methods:
- Solubility studies of nifedipine in varying concentrations of sodium benzoate and sodium salicylate solutions at different temperatures.
- Analysis of solution properties of hydrotropes to understand the solubilization mechanism.
Main Results:
- Sodium benzoate increased nifedipine solubility by 85-fold at 25°C and 76-fold at 37°C in 30% w/v solution.
- Sodium salicylate increased nifedipine solubility by 135-fold at 25°C and 107-fold at 37°C in 30% w/v solution.
- Mechanism involves hydrotrope complexation, aggregation, and inclusion of nifedipine at higher concentrations.
Conclusions:
- Sodium benzoate and sodium salicylate are effective hydrotropes for solubilizing nifedipine.
- The solubilization mechanism is concentration-dependent and involves complex interactions between the drug and hydrotropes.