Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

405
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
405
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.0K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.0K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

122
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
122
Replicative Cell Senescence02:15

Replicative Cell Senescence

4.0K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.0K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

6.1K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.1K
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

13.4K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
13.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advancing the relevance of clinical trials for older patients.

Lancet (London, England)·2026
Same author

Effectiveness of comprehensive geriatric assessment with patient coaching on toxicity, premature treatment interruption, unplanned hospitalisations, and survival in older patients with solid tumours: Secondary endpoints of the G-oncoCOACH study.

Journal of geriatric oncology·2026
Same author

Cardiovascular event burden in women with breast cancer treated with CDK4/6 inhibitors: a retrospective matched cohort study.

Cardio-oncology (London, England)·2026
Same author

Risk stratification and relapse pattern in triple-negative breast cancer with pathological complete response after neoadjuvant treatment: the European GAMBIT real-world study.

Nature communications·2026
Same author

De-escalated chemotherapy and endocrine therapy outcomes in young women with stage I HR+/HER2+ breast cancer: An international real-world study.

Breast (Edinburgh, Scotland)·2026
Same author

Identifying pre-treatment risk factors for cancer-related cognitive decline in patients with breast cancer.

Breast (Edinburgh, Scotland)·2026

Related Experiment Video

Updated: Nov 10, 2025

Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells
08:56

Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells

Published on: July 12, 2022

3.3K

Cancer and Aging: Two Tightly Interconnected Biological Processes.

Lieze Berben1, Giuseppe Floris2,3, Hans Wildiers1,4

  • 1Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, 3000 Leuven, Belgium.

Cancers
|April 3, 2021
PubMed
Summary
This summary is machine-generated.

Aging increases cancer risk and treatment challenges in older adults. Biomarkers reflecting biological age are crucial for personalized geriatric oncology, balancing treatment benefits against toxicity risks.

Keywords:
agingbiomarkerscancer

More Related Videos

A Sensitive Method to Quantify Senescent Cancer Cells
09:18

A Sensitive Method to Quantify Senescent Cancer Cells

Published on: August 2, 2013

20.9K
A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.5K

Related Experiment Videos

Last Updated: Nov 10, 2025

Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells
08:56

Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells

Published on: July 12, 2022

3.3K
A Sensitive Method to Quantify Senescent Cancer Cells
09:18

A Sensitive Method to Quantify Senescent Cancer Cells

Published on: August 2, 2013

20.9K
A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.5K

Area of Science:

  • Geriatric Oncology
  • Cancer Biology
  • Immunology

Background:

  • Aging is a primary cancer risk factor, with increasing numbers of older adults diagnosed.
  • Older cancer patients face unique challenges due to health heterogeneity and increased treatment toxicity.
  • Balancing treatment efficacy and toxicity is critical for maintaining quality of life in elderly cancer patients.

Purpose of the Study:

  • To review mechanistic links between aging and cancer.
  • To explore aging biomarkers for personalized geriatric oncology.
  • To consider age-related immune changes in cancer treatment, especially immunotherapy.

Main Methods:

  • Literature review of aging mechanisms in cancer.
  • Analysis of current knowledge on aging biomarkers.
  • Examination of age's impact on systemic immunity and tumor immune infiltrate.

Main Results:

  • Biological changes associated with aging contribute to cancer development.
  • Aging impacts immune system function and tumor microenvironment, relevant to immunotherapy.
  • Heterogeneity in older adults necessitates individualized treatment approaches.

Conclusions:

  • Robust biomarkers of biological age are needed for optimal cancer treatment in older patients.
  • Understanding aging's role in immunity is vital for advancing geriatric oncology and immunotherapy.
  • Personalized strategies are essential to avoid both over- and under-treatment in elderly cancer care.