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Published on: September 3, 2013
Dynamic Contrast-Enhanced MRI of Prostate Lesions of Simultaneous [68Ga]Ga-PSMA-11 PET/MRI: Comparison between
Jing Zhao1, Avan Kader1,2, Dilyana B Mangarova1,3
1Institute of Radiology and Nuclear Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany.
Abstract:
We aimed to retrospectively compare the perfusion parameters measured from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) of prostate benign lesions and malignant lesions to determine the relationship between perfusion parameters. DCE-MRI was performed in patients with PCa who underwent simultaneous [68Ga]Ga-prostate-specific membrane antigen (PSMA)-11 positron emission tomography (PET)/MRI. Six perfusion parameters (arrival time (AT), time to peak (TTP), wash-in slope (W-in), wash-out slope (W-out), peak enhancement intensity (PEI), and initial area under the 60-s curve (iAUC)), and a semi-quantitative parameter, standardized uptake values maximum (SUVmax) were calculated by placing regions of interest in the largest area of the lesions. The DCE-MRI parameters between prostate benign and malignant lesions were compared. The DCE-MRI parameters in both the benign and malignant lesions subgroup with SUVmax ≤ 3.0 and SUVmax > 3.0 were compared. The correlation of DCE-MRI parameters was investigated. Malignant lesions demonstrated significantly shorter TTP and higher SUVmax than did benign lesions. In the benign and malignant lesions subgroup, perfusion parameters of lesions with SUVmax ≤ 3.0 show no significant difference to those with SUVmax > 3.0. DCE-MRI perfusion parameters show a close correlation with each other. DCE-MRI parameters reflect the perfusion characteristics of intraprostatic lesions with malignant lesions, demonstrating significantly shorter TTP. There is a moderate to strong correlation between DCE-MRI parameters. Semi-quantitative analysis reflects that malignant lesions show a significantly higher SUVmax than benign lesions.
Insights
Dynamic contrast-enhanced MRI (DCE-MRI) reveals shorter time to peak (TTP) in malignant prostate lesions compared to benign ones. Perfusion parameters correlate moderately to strongly, aiding in lesion characterization.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Prostate cancer (PCa) diagnosis relies on accurate lesion characterization.
- Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) offers insights into tissue perfusion.
- [68Ga]Ga-PSMA-11 positron emission tomography (PET)/MRI combines anatomical, functional, and metabolic imaging.
Purpose of the Study:
- To compare DCE-MRI perfusion parameters between benign and malignant prostate lesions.
- To investigate the relationship between DCE-MRI perfusion parameters and SUVmax.
- To assess the diagnostic utility of DCE-MRI parameters in differentiating prostate lesions.
Main Methods:
- Retrospective analysis of DCE-MRI data in PCa patients undergoing simultaneous [68Ga]Ga-PSMA-11 PET/MRI.
- Calculation of six DCE-MRI perfusion parameters (AT, TTP, W-in, W-out, PEI, iAUC) and SUVmax.
- Comparison of parameters between benign and malignant lesions, and subgroups based on SUVmax.
Main Results:
- Malignant lesions showed significantly shorter TTP and higher SUVmax than benign lesions.
- No significant difference in perfusion parameters was observed between SUVmax subgroups (≤3.0 vs. >3.0).
- DCE-MRI perfusion parameters demonstrated moderate to strong correlations with each other.
Conclusions:
- DCE-MRI perfusion parameters effectively reflect intraprostatic lesion characteristics.
- Shorter TTP is a key indicator of malignancy in prostate lesions.
- DCE-MRI parameters are closely correlated, enhancing their potential for diagnostic assessment.
