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Types of Step-Growth Polymers: Polyesters01:20

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The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
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Exploring Charged Polymeric Cyclodextrins for Biomedical Applications.

Noemi Bognanni1, Francesco Bellia2, Maurizio Viale3

  • 1Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy.

Molecules (Basel, Switzerland)
|April 3, 2021
PubMed
Summary
This summary is machine-generated.

New cyclodextrin polymers show promise for drug delivery and treating protein misfolding diseases. These polymers inhibit amyloid-beta aggregation and can alter drug toxicity, particularly doxorubicin in A2780 cells.

Keywords:
aggregationcancerdoxorubicinnanoparticles

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Area of Science:

  • Biomedical applications
  • Polymer chemistry
  • Drug delivery systems

Background:

  • Cyclodextrins are versatile molecules with established biomedical applications.
  • They are utilized for drug transport and investigated as molecular chaperones for protein misfolding diseases.

Purpose of the Study:

  • To design and evaluate novel cyclodextrin polymers with varying beta- or gamma-cyclodextrin content and guanidinium charge.
  • To explore the impact of polymer charge on drug delivery and anti-aggregation properties.
  • To assess the polymers' efficacy in inhibiting amyloid-beta peptide aggregation and their effect on drug cytotoxicity.

Main Methods:

  • Synthesis of cyclodextrin polymers with controlled beta-/gamma-cyclodextrin content and guanidinium charge.
  • Assessment of polymers' ability to inhibit amyloid-beta peptide aggregation.
  • Evaluation of doxorubicin cytotoxicity in A2780, A549, and MDA-MB-231 cell lines in the presence of the designed polymers.

Main Results:

  • The synthesized cyclodextrin polymers demonstrated inhibition of amyloid-beta peptide aggregation.
  • The anti-aggregation efficacy was found to be dependent on both the cyclodextrin cavity type and the number of positive charges.
  • Polymers based on gamma-cyclodextrin altered doxorubicin's cytotoxicity specifically in the A2780 cell line.

Conclusions:

  • Novel cyclodextrin polymers exhibit potential for therapeutic applications in protein misfolding diseases.
  • These polymers can modulate drug delivery and cytotoxicity, suggesting tailored applications in cancer therapy.
  • The study highlights the importance of polymer design, specifically charge and cyclodextrin type, for optimizing therapeutic outcomes.