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Oxidative metabolites of 5-nitrofurans
A J Streeter1, T R Krueger, B A Hoener
1Department of Pharmacy, School of Pharmacy, University of California, San Francisco.
Pharmacology
|January 1, 1988
Abstract:
We synthesized the 4-hydroxy derivatives of nitrofurazone, furazolidone and nitrofurantoin. Then we dosed rats orally with these antibiotics and isolated the intensely yellow, polar metabolites from their urine. A comparison of the ultraviolet and nuclear magnetic resonance spectra of these metabolites with the corresponding synthetic derivatives confirmed that the metabolites are 4-hydroxynitrofurazone, 4-hydroxyfurazolidone and 4-hydroxynitrofurantoin.