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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
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Proven Fatal Invasive Aspergillosis in a Patient with COVID-19 and Staphylococcus aureus Pneumonia

Frank van Someren Gréve1, Romy du Long2, Raju Talwar3

  • 1Department of Medical Microbiology, Amsterdam University Medical Centers, 1105 AZ Amsterdam, The Netherlands.

Journal of Fungi (Basel, Switzerland)
|April 3, 2021
PubMed

Insights

Opportunistic fungal infections like Aspergillus fumigatus are a concern in severe COVID-19. This case confirms COVID-19-associated pulmonary aspergillosis via post-mortem lung biopsy culture.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pulmonology

Background:

  • Rising incidence of opportunistic fungal infections complicating severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) in critically ill patients.
  • Challenges in diagnosing invasive fungal diseases due to the need for invasive procedures for definitive diagnosis.

Observation:

  • A critically ill patient with SARS-CoV-2 infection developed complications.
  • Diagnostic procedures for invasive fungal disease can be invasive and challenging.

Findings:

  • This report details one of the first proven cases of COVID-19-associated pulmonary aspergillosis.
  • Diagnosis was confirmed by positive culture of *Aspergillus fumigatus* from a post-mortem lung biopsy.

Implications:

  • Highlights the importance of considering invasive aspergillosis in SARS-CoV-2 patients.
  • Post-mortem lung biopsy is a valuable tool for confirming invasive pulmonary aspergillosis in complex cases.
  • Underscores the diagnostic challenges and potential severity of co-infections in critically ill COVID-19 patients.
Keywords:
Aspergillus fumigatusCOVID-19Invasive AspergillosisSARS-CoV-2

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