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Updated: Nov 10, 2025

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter
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DNA Double-Strand Breaks Affect Chromosomal Rearrangements during Methotrexate-Mediated Gene Amplification in Chinese

Jong Youn Baik1,2,3, Hye-Jin Han3, Kelvin H Lee1,2

  • 1Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA.

Pharmaceutics
|April 3, 2021
PubMed

Keywords:
Chinese hamster ovary (CHO) cellsDNA double-strand breaks (DSBs)biomanufacturingcell line instability and clonalitychromosomal rearrangementsmethotrexate (MTX)

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