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Updated: Nov 10, 2025

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

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Published on: April 17, 2013

Additional Tissue Sampling Trials Did Not Change Our Thyroid Practice.

Hisakazu Shindo¹, Kennichi Kakudo², Keiko Inomata³

¹Department of Surgery, Yamashita Thyroid Hospital, Fukuoka 812-0034, Japan.

|April 3, 2021

Summary

This summary is machine-generated.

Additional tissue sampling for encapsulated thyroid nodules did not significantly increase follicular thyroid carcinoma (FTC) diagnoses. This practice yielded no clinical benefit for patients, leading to its discontinuation in thyroid cancer diagnosis.

Keywords:

capsular invasion follicular thyroid carcinoma overdiagnosis sampling method vascular invasion

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Area of Science:

Endocrinology
Pathology
Surgical Oncology

Background:

Follicular thyroid carcinoma (FTC) diagnosis relies on pathological assessment of thyroid nodules.
The efficacy of increased tissue sampling in improving FTC detection rates requires further investigation.

Purpose of the Study:

To evaluate if additional tissue sampling of encapsulated thyroid nodules enhances the diagnostic frequency of follicular thyroid carcinoma (FTC).

Main Methods:

Retrospective analysis of thyroid tissue specimens from 86 patients with suspected FTC.
Comparison of diagnoses based on standard pathological assessment versus methods including additional tissue blocks.

Main Results:

Additional tissue sampling revised one diagnosis from follicular adenoma to FTC, increasing the FTC diagnosis count from 5 to 6.
Despite a slight increase in FTC detection, the change was not clinically significant for patient management.

Conclusions:

Additional tissue sampling for encapsulated thyroid nodules did not substantially improve FTC diagnosis rates.
The practice offered no discernible benefit to patient treatment strategies, leading to its cessation.