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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Related Experiment Video

Updated: Nov 10, 2025

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Trematode Proteomics: Recent Advances and Future Directions.

Adam P S Bennett¹, Mark W Robinson¹

¹School of Biological Sciences, Queen's University Belfast, 19 Chlorine Gardens, Belfast BT9 5DL, Northern Ireland, UK.

Pathogens (Basel, Switzerland)

|April 3, 2021

Summary

This summary is machine-generated.

Emerging drug resistance in trematodes necessitates new treatments. Advanced proteomics reveals parasite secrets, identifying potential vaccine targets and drug strategies against these widespread fluke infections.

Keywords:

excretory–secretory host–parasite interactions mass spectrometry proteomics secretome trematode

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Last Updated: Nov 10, 2025

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Published on: November 15, 2017

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Cell-Lineage Guided Mass Spectrometry Proteomics in the Developing Frog Embryo

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Area of Science:

Parasitology
Molecular Biology
Immunology

Background:

Trematodes infect millions globally, with limited treatment options and emerging drug resistance.
Understanding parasite biology and host interactions is crucial for developing new vaccines and therapies against fluke infections.

Purpose of the Study:

To review recent advances in mass spectrometry-based proteomics for studying trematode parasites.
To highlight how proteomics aids in identifying new drug targets and vaccine candidates.

Main Methods:

Mass spectrometry-based proteomics to analyze trematode proteomes.
Integration of transcriptome and proteome datasets.
Immunoproteomics to identify vaccine candidates.
Emerging technologies like laser microdissection and single-cell proteomics.

Main Results:

Proteomics of extracellular vesicles offers insights into fluke biogenesis and host interactions.
Integrated omics data reveal developmental regulation of virulence factors and immunomodulators.
Immunoproteomics successfully identifies potential vaccine targets linked to protective antibodies.

Conclusions:

Proteomics is a key tool for unraveling trematode biology and host interactions.
Advanced proteomic techniques can pinpoint novel targets for controlling fluke infections and developing effective vaccines.