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Alterations of Left Ventricular Function Persisting during Post-Acute COVID-19 in Subjects without Previously

Mariana Tudoran1,2,3, Cristina Tudoran1,2, Voichita Elena Lazureanu4

  • 1Department VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania.

Journal of Personalized Medicine
|April 3, 2021
PubMed

Insights

Post-COVID-19 patients often experience persistent cardiac issues, including left ventricular systolic function alterations and diastolic dysfunction. Elevated myocardial necrosis markers during acute infection may predict future cardiac performance decline.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Echocardiography

Background:

  • Coronavirus disease (COVID-19) is a severe respiratory illness with known cardiovascular complications.
  • This study investigates persistent cardiac dysfunction in COVID-19 survivors without prior cardiovascular disease.

Purpose of the Study:

  • To assess left ventricular systolic function (LV-SF) and diastolic dysfunction (DD) in COVID-19 patients post-recovery.
  • To identify predictors of cardiac dysfunction following moderate COVID-19 pneumonia.

Main Methods:

  • 125 patients hospitalized for moderate COVID-19 pneumonia underwent transthoracic echocardiography (TTE) 6-10 weeks after discharge.
  • Analysis included in-hospital laboratory data (CK-MB) and thorax CT scans.
  • Multivariate regression identified factors associated with LV-SF decrease.

Main Results:

  • Transthoracic echocardiography revealed LV-SF alterations in 8.8% and diastolic dysfunction in 16.8% of patients.
  • Cardiac dysfunction correlated with initial levels of creatine kinase-MB (CK-MB) and inflammatory markers.
  • CK-MB levels, age, and BMI accounted for 65% of the decrease in LV-SF.

Conclusions:

  • Left ventricular systolic and diastolic dysfunction are common sequelae of COVID-19 infection.
  • These cardiac alterations may contribute to persistent symptoms in post-acute COVID-19.
  • Elevated myocardial necrosis markers during acute COVID-19 infection predict subsequent cardiac performance impairment.

Keywords:
COVID-19cytokine stormdiastolic dysfunctionheart failureinflammationleft ventricular systolic dysfunctiontransthoracic echocardio-graphy

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