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Uric acid in chronic coronary syndromes: Relationship with coronary artery disease severity and left ventricular

Alessandro Maloberti1, Irene Bossi2, Elena Tassistro3

  • 1Cardiology IV, "A.De Gasperis" Department, Ospedale Niguarda Ca' Granda, Milan, Italy; School of Medicine and Surgery, Milano-Bicocca University, Milan, Italy.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|April 3, 2021
PubMed

Insights

High uric acid (UA) levels did not correlate with coronary artery disease or diastolic dysfunction in patients with chronic coronary syndromes (CCS). Further research may explore UA

Area of Science:

  • Cardiology
  • Clinical Research
  • Biochemistry

Background:

  • Uric acid (UA) is linked to cardiovascular (CV) events in chronic coronary syndromes (CCS).
  • Hypotheses suggest UA may worsen coronary atherosclerosis or cause diastolic dysfunction.
  • This study investigated these potential roles of UA.

Purpose of the Study:

  • To determine if uric acid levels are associated with the severity of coronary artery disease in CCS patients.
  • To investigate the relationship between uric acid levels and left ventricular (LV) diastolic dysfunction in CCS patients.

Main Methods:

  • 231 CCS patients from Niguarda Hospital (Jan 2017-June 2018) were analyzed.
  • Coronary angiography assessed atherosclerotic burden (vessel involvement, Gensini/Syntax scores).
  • Echocardiography evaluated systolic and diastolic function.

Main Results:

  • Uric acid levels showed no significant association with coronary angiography findings (vessel number/type, Gensini/Syntax scores).
  • UA levels were not significantly linked to echocardiographic parameters of systolic or diastolic function.
  • No correlation was found between UA and disease severity or LV diastolic dysfunction in CCS.

Conclusions:

  • Uric acid does not appear to play a role in established coronary artery disease or LV diastolic dysfunction in CCS patients.
  • UA might influence cardiovascular health in earlier disease stages.
  • In advanced CCS, other factors may overshadow the effects of uric acid.
Abstract

Keywords:
Chronic coronary syndromesCoronary artery diseaseDiastolic dysfunctionUric acid

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