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Redox-related biomarkers in physical exercise
Mari Carmen Gomez-Cabrera1, Aitor Carretero1, Fernando Millan-Domingo1
1Freshage Research Group, Department of Physiology. Faculty of Medicine, University of Valencia and CIBERFES. Fundación Investigación Hospital Clínico Universitario/INCLIVA, Valencia, Spain.
Redox Biology
|April 3, 2021
Summary
Exercise redox biology has advanced significantly, revealing the role of reactive oxygen species in muscle function and adaptation. This review covers key findings and discusses biomarkers for assessing exercise-induced oxidative stress and recovery.
Area of Science:
- Exercise physiology
- Redox biology
- Skeletal muscle function
Background:
- The field of exercise redox biology has evolved over 70 years.
- Early research focused on free radicals in skeletal muscle.
- Significant discoveries link exercise to oxidative damage and redox regulation.
Purpose of the Study:
- To review major research findings in exercise redox biology.
- To explore the role of reactive oxygen species in muscle adaptation.
- To evaluate biomarkers for assessing exercise-related health and performance.
Main Methods:
- Historical review of exercise redox biology research.
- Analysis of reactive oxygen species sources and functions during exercise.
- Comprehensive review of redox biomarkers (oxidants, antioxidants, oxidation products, redox balance).
Main Results:
- Exercise involves complex redox processes impacting skeletal muscle.
- Reactive oxygen species play regulatory roles in gene transcription and muscle adaptation.
- Various biomarkers exist for assessing oxidative stress, damage, and recovery.
Conclusions:
- Exercise redox biology is crucial for understanding muscle function and adaptation.
- Careful selection and interpretation of biomarkers are essential for sports science.
- Further research is needed to refine biomarker utility in athletic populations.
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