Related Experiment Video

Updated: Nov 10, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

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The roles and regulation of the KLF5 transcription factor in cancers

Yao Luo1,2, Ceshi Chen2

  • 1Medical Faculty of Kunming University of Science and Technology, Kunming, China.

Cancer Science
|April 3, 2021
PubMed

Insights

Krüppel-like factor 5 (KLF5) is a key regulator of cellular functions and gene expression. Research highlights its role in cancer, suggesting KLF5 as a potential target for cancer therapies.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Cancer Research

Background:

  • Krüppel-like factor 5 (KLF5) is a transcription factor involved in numerous cellular processes.
  • KLF5 regulates genes related to stemness, proliferation, apoptosis, autophagy, and migration.
  • Its activity is modulated by signaling pathways, transcriptional, and posttranslational modifications.

Purpose of the Study:

  • To explore the multifaceted roles of Krüppel-like factor 5 (KLF5) in cellular functions.
  • To investigate the involvement of KLF5 in various cancer types.
  • To identify KLF5 as a potential prognostic biomarker and therapeutic target in oncology.

Main Methods:

  • Review of recent studies on KLF5 gene regulation and function.
  • Analysis of data from transgenic mouse models.
  • Examination of KLF5's role in diverse signaling pathways.

Main Results:

  • KLF5 influences critical cellular processes including stemness and proliferation.
  • KLF5 plays a significant role in the pathophysiology of various cancers.
  • Transgenic mouse models demonstrate KLF5's physiological and pathological relevance.

Conclusions:

  • KLF5 is a crucial regulator with implications in cancer development and progression.
  • KLF5 presents a promising target for the development of novel cancer therapeutics.
  • Further studies on KLF5 may lead to new prognostic biomarkers and drugs for cancer treatment.
Keywords:
posttranslational modificationsignaling pathwaytargeted therapytranscription

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