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Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving

Simona Pace1, Kehong Zhang2, Paul M Jordan1

  • 1Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Philosophenweg 14, D-07743 Jena, Germany.

Pharmacological Research
|April 3, 2021
PubMed

Keywords:
5-lipoxygenaseCelastrolInflammationLeukotrieneMK886 (PubChem CID: 3651377)Specialized pro-resolving mediatorsarachidonic acid (PubChem CID: 444899)celastrol (PubChem CID: 122724)celecoxib (PubChem CID: 2662)dimethyl sulfoxide (PubChem CID: 679)indomethacin (PubChem CID: 3715)resolvin D5 (PubChem CID: 16061139)zileuton (PubChem CID: 60490)zymosan (PubChem CID: 64689)

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