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Acute sunitinib neurotoxicity

Ahmet Gulmez1, Mustafa Dikilitas1, Emin Tamer Elkiran1

  • 1Inonu University Medical Oncology Department, Malatya Turkey.

Cancer Treatment and Research Communications
|April 3, 2021
PubMed

Insights

Sunitinib malate, a targeted cancer therapy, can rarely cause serious neurotoxicity. This case report details neurological side effects linked to increased vascular endothelial growth factor (VEGF) during sunitinib treatment.

Area of Science:

  • Oncology
  • Pharmacology
  • Neuroscience

Background:

  • Sunitinib malate is an oral tyrosine kinase inhibitor (TKI) used for metastatic renal cell carcinoma.
  • Common side effects include diarrhea, mucositis, asthenia, and myelosuppression.
  • Serious toxicities are rare but documented.

Observation:

  • This case report focuses on neurotoxicity associated with sunitinib malate.
  • The observed neurotoxicity occurred within two weeks of treatment initiation.
  • Elevated vascular endothelial growth factor (VEGF) levels are implicated.

Findings:

  • Sunitinib malate inhibits tyrosine kinases, leading to increased VEGF levels.
  • Increased VEGF is hypothesized to contribute to neurological side effects.
  • A rare case of sunitinib-induced neurotoxicity is presented.

Implications:

  • Understanding the mechanism of sunitinib neurotoxicity is crucial for patient safety.
  • Monitoring for neurological symptoms in patients receiving sunitinib is important.
  • Further research into VEGF's role in TKI-related neurotoxicity is warranted.
Keywords:
NeurotoxicityRenal cell cancerTyrosine Kinase Inhibitor

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