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Rabies: Presentation, case management and therapy.

Pasin Hemachudha1, Thiravat Hemachudha1

  • 1Thai Red Cross Emerging Infectious Diseases-Health Science Centre, World Health Organization Collaborating Centre for Research and Training on Viral Zoonoses, Chulalongkorn Hospital, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Journal of the Neurological Sciences
|April 3, 2021
PubMed
Summary
This summary is machine-generated.

Rabies treatment remains challenging, but favipiravir shows promise in reducing viral replication. The endocannabinoid system may offer neuroprotection by promoting cell survival and autophagy in infected cells.

Keywords:
EndocannabinoidFavipiravirLyssavirusRabies

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Area of Science:

  • Virology
  • Neuroscience
  • Pharmacology

Background:

  • Rabies, caused by Lyssaviruses, lacks effective treatments for symptomatic patients.
  • Viral eradication in the central nervous system (CNS) is hindered by inadequate immune responses.
  • Deep bites from infected dogs pose the highest risk of rabies transmission.

Purpose of the Study:

  • To investigate the potential of favipiravir in inhibiting rabies virus replication.
  • To explore the neuroprotective role of the endocannabinoid system in rabies infection.

Main Methods:

  • Utilized neuronal cell and mouse models to assess favipiravir's efficacy.
  • Examined the influence of cannabinoids on CNS homeostasis during rabies infection.

Main Results:

  • Favipiravir demonstrated selective inhibition of viral RNA polymerase, reducing rabies replication.
  • The endocannabinoid system emerged as a key regulator of CNS integrity and cell fate.
  • Cannabinoids may restore homeostasis by enhancing infected cell survival and promoting autophagy.

Conclusions:

  • Favipiravir shows potential for reducing rabies viral load.
  • The endocannabinoid system presents a novel therapeutic target for neuroprotection in rabies.